University of Pittsburgh - Of the Commonwealth System of Higher Education
发明人:
Ross, Ted M.,Carter, Donald M.,Crevar, Corey J.
申请号：
AU2017204454
公开号：
AU2017204454A1
申请日:
2017.06.29
申请国别(地区):
AU
年份:
2017
代理人:
摘要：
#$%^&*AU2017204454A120170720.pdf#####ABSTRACT COMPUTATIONALLY OPTIMIZED BROADLY REACTIVE ANTIGENS FOR H3N2, H2N2, AND B INFLUENZA VIRUSES Described herein is the generation of optimized H3N2, H2N2 and B influenza HA polypeptides for eliciting a broadly reactive immune response to influenza virus isolates. The optimized HA polypeptides were developed through a series of HA protein alignments, and subsequent generation of consensus sequences, based on H3N2, H2N2 and B influenza isolates. Provided herein are optimized H3N2, H2N2 and B influenza HA polypeptides, and compositions, fusion proteins and VLPs comprising the HA polypeptides. Further provided are codon-optimized nucleic acid sequences encoding the HA polypeptides. Methods of eliciting an immune response against influenza virus in a subject are also provided by the present disclosure.
