Refers to a sustained-release composition comprising a therapeutically effective amount of a bioactive agent which is a compound that is selected from the group of anthelmintic avermectin, Moxidectin, among others, an aqueous Carrier, which is selected from Corn Oil, Oil Peanut,Amongst others and a Solvent System comprising Castor Oil and at least one cyclic amide is a pyrrolidone.SE REFIERE A UNA COMPOSICION DE ACCION PROLONGADA QUE COMPRENDE UNA CANTIDAD TERAPEUTICAMENTE EFICAZ DE UN AGENTE BIOACTIVO, QUE ES UN COMPUESTO ANTIHELMINTICO QUE SE SELECCIONA DEL GRUPO DE AVERMECTINA, MOXIDECTINA, ENTRE OTROS UN PORTADOR NO ACUOSO, QUE SE SELECCIONA DE ACEITE DE MAIZ, ACEITE DE MANI, ENTRE OTROS Y UN SISTEMA SOLVENTE QUE COMPRENDE ACEITE DE RICINO Y AL MENOS UNA AMIDA CICLICA QUE ES UNA PIRROLIDONA.