KINNEER, KRISTA,VARKEY, REENA,XIAO, XIAODONG,HURT, ELAINE M.,TICE, DAVID
申请号：
CA3070539
公开号：
CA3070539A1
申请日:
2018.07.31
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
The disclosure is directed to an antibody-drug conjugate (ADC) comprising amonoclonal antibody, or an antigen-bind-ing fragment thereof, directed against B-cell maturation antigen (BCMA)conjugated to a cytotoxin. The disclosure also provides com-positions comprising the antibody-drug conjugate and methods of killingmultiple myeloma cells (including multiple myeloma stemscells) that express BCMA by contacting multiple myeloma cells with the ADC.
