KINNEER, Krista,VARKEY, Reena,XIAO, Xiaodong,HURT, Elaine M.,TICE, David
申请号：
AU2018311503
公开号：
AU2018311503A1
申请日:
2018.07.31
申请国别(地区):
AU
年份:
2020
代理人:
摘要：
The disclosure is directed to an antibody-drug conjugate (ADC) comprising a monoclonal antibody, or an antigen-binding fragment thereof, directed against B-cell maturation antigen (BCMA) conjugated to a cytotoxin. The disclosure also provides compositions comprising the antibody-drug conjugate and methods of killing multiple myeloma cells (including multiple myeloma stems cells) that express BCMA by contacting multiple myeloma cells with the ADC.
