Sergei M. GRYAZNOV,Daria ZIELINSKA,Ronald A. PRUZAN,Jeffrey N. LINDQUIST
申请号：
HK16102007.9
公开号：
HK1214293A
申请日:
2016.02.23
申请国别(地区):
HK
年份:
2016
代理人:
摘要：
Provided herein are antisense oligonucleotides that can effectively prevent or decrease c-myc protein expression as well as decrease overall rates of cell proliferation in in vitro and mammalian in vivo models of cell proliferative disorders as well as methods for using the same. The antisense oligonucleotides comprise at least one phosphoramidate (NP)-modified or thiophosphoramidate (NPS)-modified intersubunit linkage.
