The invention relates to a device that provides enhanced mechanical stabilization, as well as methods for its use. In various embodiments, the device is configured in a manner similar to a conventional screw, but with mechanical elements that afford greater fixation and stability and that lessen the likelihood that the device loosens after insertion into a substrate and/or falls out of the substrate entirely or releases its interaction with the substrate. Moreover, the device may have better pullout strength as compared with conventional screws and screw-type devices used in a range of applications.