The design and integrated approach in the libraries ARNP, the library in the libraries ARNIP, the molecule of Arnip molecules and its use. 1.It is required that 1: a method of one small-scale interference library (ARNP) of design, including one polymolecular Arn molecule of synthesis Each molecule of Ah grace include the seed containing seedless agent and one non-seed sequence one include target mechanism one or more microorganism sequences one or more microorganism sequences seed this be not the seed for having nucleon