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ПРОИЗВОДНЫЕ ДИГИДРОЛИПОЕВОЙ КИСЛОТЫ, СОДЕРЖАЩИЕ ОКСИД АЗОТА, И ИХ ТЕРАПЕВТИЧЕСКИЕ ПРИМЕНЕНИЯ
专利权人:
ИНВАСК ТЕРАПЬЮТИКС; ИНК. (US)
发明人:
ПАРТАСАРАТИ Сэмпат (US)
申请号:
RU2012103757/04
公开号:
RU2012103757A
申请日:
2010.02.19
申请国别(地区):
RU
年份:
2013
代理人:
摘要:
1. A compound having the formula (I):.Where:m - an integer from 1 to 2n - an integer from 1 to 10R1 and R2 are independently selected from the group consisting of H, methyl, ethyl, propyl, butyl, isopropyl, isobutyl, and tert-butyl andR3 is selected from the group consisting of COOH, COOCH3, COOCH2CH3.. . . .and .or a pharmaceutically acceptable salt or solvate thereof.2. A compound according to claim 1, wherein the compound has the Formula (II):.3. A compound according to claim 1, wherein the compound has the Formula (III):.4. A compound of claim 1, wherein the compound has the Formula (IV):.5. A compound of claim 1, wherein the compound has the Formula (V):6. A compound of claim 1, wherein the compound has the Formula (VI):.7. The compound of claim 1, wherein the compound has the Formula (VII):.8. The compound of claim 1, wherein the compound has the Formula (VIII):.9. The compound of claim 1, wherein the compound has the Formula (IX):.10. The compound of claim 1, wherein the compound has the Formula (X):.11. The compound of claim 1, wherein the compound has the Formula (XI):.12. The compound of claim 1, wherein the compound has the Formula (XII):.13. The compound of claim 1, wherein the compound has the Formula (XIII):.14. The compound of claim 1, wherein the compound has the Formula (XIV):.15. A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable excipient, carrier or excipient.16. A compound having the formula (XV):.Where:R1 and R2 are independently selected from the group consisting of H, CH3And tert-butyl andR3 is selected from the group consisting of CH2SNSNSN2COOCH3, CH2SNSNSNSNSOON and SNSNSNSNSOOSN2CH3or a pharmaceutically acceptable salt or solvate thereof.17. The compound of claim 16, wherein the compound has the Formula (XVI):18. The compound of claim 16, wherein the compound has formula (XVII):.19. The compound of claim 16, wherein the compound has the Formula (XVIII):.20. A method for increasing vasodilation,
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