ЛАУ Еспер Ф. (DK),КРУСЕ Томас (DK),ТЁГЕРСЕН Хеннинг (DK),КРОГ Томас Нюланнстед (DK),СЕНСФУСС Ульрих (DK)
申请号：
RU2013145013/04
公开号：
RU2013145013A
申请日:
2012.03.28
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. Derived glucagon peptide with the formula [I]: containing a Deputy attached to the nitrogen atom of the side chain amino acids at positions X, X, X, X, X, X, X, and / or X specified glucagon peptide, where the specified Deputy has the formula II : where Y, Y, Y, Y, Y, Y, Y, Y, Y, Y, and Y are individually absent or individually are amino acids i, ii, iii or iv that have the stereochemistry L or D or structure v :, and Y is absent or represents a C-acyl group or a succinoyl group, provided that the substituent of formula II contains from three to ten five negatively charged groups, or a pharmaceutically acceptable salt, amide or carboxylic kislota.2. The glucagon peptide derivative of claim 1, wherein: Y is absent or is an amino acid such as, but not limited to Arg, ε-Lys or Gly； Y, Y, Y, Y, Y, Y, Y, Y, Y, or Y individually absent or individually represent amino acids i or ii ；； and Y is absent or represents the structure of formulas vi, vii, viii, ix, x or xi: .3. The glucagon peptide derivative of claim 2, wherein: Y is absent or is an amino acid Arg, ε-Lys or Gly； Y, Y, Y, Y, Y, Y, Y, Y, Y, or Y are individually absent or individually are i or ii ；； and Y is absent or represents the structure of formulas vi, vii, viii, ix, x or xi: .4. The glucagon peptide derivative of claim 1, wherein said substituent is attached to the side chain of an amino acid at the position of the indicated glucagon peptide. The glucagon peptide derivative of claim 4, wherein X is Lys. 6. The glucagon peptide derivative of claim 1, wherein said glucagon peptide contains up to 15 substitutions of amino acid residues and where: X is Ser, Aib, Thr, A1. Производное глюкагонового пептида с формулой [I]:содержащее заместитель, присоединенный к атому азота боковой цепи аминокислоты в позициях X, X, X, X, X, Х, Х, и/или Хуказанного глюкагонового пептида, где указанный заместитель имеет формулу II:,гдеY, Y, Y, Y, Y, Y, Y, Y, Y, Yи Yпо отдельности отсутствуют или по отдельности представляют собой
