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DERIVE D'IMIDAZOLE DI-SUBSTITUE EN 1,4
专利权人:
LTD.;SUMITOMO DAINIPPON PHARMA CO.
发明人:
BAN, HITOSHI,KUSAGI, MANABU,TOJO, SHINGO,HASEGAWA, FUTOSHI,HASHIZUME, MIKI
申请号:
CA2990583
公开号:
CA2990583A1
申请日:
2016.06.21
申请国别(地区):
CA
年份:
2016
代理人:
摘要:
The present invention provides: a 1,4-di-substituted imidazole derivative that is represented by formula (1'), that shows excellent cancer cell sphere forming ability suppressing effect, and that is useful as an orally administrable antitumor agent; and a pharmaceutically acceptable salt thereof. [In the formula, ring Q1 represents an optionally substituted C6-10 aryl group or the like, R1 and R2 independently represent a hydrogen atom or the like, W1 represents an optionally substituted C1-4 alkylene group, W2 represents -NR3aC(O)- or the like (wherein, R3a represents a hydrogen atom or a C1-6 alkyl group); ring Q2 represents a 5-10 membered heteroaryl group; W3 represents an optionally substituted C1-4 alkylene group or the like; n represents 1, 2, 3, 4, or 5; R4 represents, independently when more than one thereof exists, a hydrogen atom, an optionally substituted C1-6 alkyl group, or the like; and R5 represents a hydroxy group or the like.]
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