您的位置: 首页 > 农业专利 > 详情页

Ultralong complementarity determining regions and uses thereof
专利权人:
The Scripps Research Institute
发明人:
BAZIRGAN, Omar A.,MAO, Hongyuan Helen,SMIDER, Vaughn,EKIERT, Damian,SCHULTZ, Peter,WANG, Feng,WILSON, Ian,ZHANG, Yong
申请号:
AU2018201832
公开号:
AU2018201832A1
申请日:
2018.03.14
申请国别(地区):
AU
年份:
2018
代理人:
摘要:
#$%^&*AU2018201832A120180412.pdf#####ULTRALONG COMPLEMENTARITY DETERMINING REGIONS AND USES THEREOF ABSTRACT Disclosed herein are immunoglobulin consturcts comprising at least one immunoglobulin domain or fragment thereof; and a therapeutic polypeptide or derivative or variant thereof attached to or inserted into said immunoglobulin domain. Also provided are immunoglobulin constructs comprising a mammalian immunoglobulin heavy chain comprising at least a portion of a knob domain in the complementarity - determining region 3 (CDR3H) or fragment thereof; and a therapeutic polypeptide attached to or inserted into said knob domain of the CDR3H. Also provided are immunoglobulin constructs comprising a mammalian immunoglobulin heavy chain comprising at least a portion of a stalk domain in the complementarity-determining region 3 (CDR3H) or fragment thereof; and a therapeutic polypeptide attached to or inserted into said stalk domain of the CDR3H. Also described herein are methods and compositions comprising the immunoglobulin constructs described herein for treatment and prevention of a disease or condition in a subject.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充