用於治療病毒性肝炎之非晶型水飛薊賓农业专利-农业学术服务平台

发明人:: ROVATI, LUCIO CLAUDIO,罗瓦蒂　鲁西欧　克劳蒂欧,羅瓦蒂　魯西歐　克勞蒂歐,NAGELL, ASTRID,纳吉尔　阿丝特丽德,納吉爾　阿絲特麗德,XIOL, JAIME AGUIRRE,希欧　杰米　阿吉雷,希歐　傑米　阿吉雷,RULL, SANTIAGO PROUS,鲁尔　圣地牙哥　普劳尔斯,魯爾　聖地牙哥　普勞爾斯,POHL, RALF-TORSTEN,波尔　哈夫　托斯腾,波,罗瓦蒂鲁西欧克劳蒂欧,羅瓦蒂魯西歐克勞蒂歐,纳吉尔阿丝特丽德,納吉爾阿絲特麗德,希欧杰米阿吉雷,希歐傑米阿吉雷,鲁尔圣地牙哥普劳尔斯,魯爾聖地牙哥普勞爾斯,波尔哈夫托斯腾

摘要：: The invention relates to a method for the preparation of amorphous silibinin (or its synonyms: silybin or silibin) derived from a milk thistle fruit extract having an increased release rate and improved absorbability or bioavailability, and to the use of amorphous silibinin for the treatment or prevention of liver diseases, preferably for the treatment of viral hepatitis, e.g. hepatitis B or C, in particular in a patient who will undergo or has undergone liver transplantation. Preferably, the amorphous silibinin is adapted for oral administration.本發明關係到一用於製備非晶型水飛薊賓(silibinin)(或其同義辭silybin或silibin)之方法，該化合物係源自於水飛薊果實之萃取液，具有增加之釋出率及經過改善之可吸收性或生物可利用率，且關係到使用非晶型水飛薊賓於治療或預防肝臟疾病，較佳用於治療病毒性肝炎，例如B型或C型肝炎，尤其是用於即將或已經接受肝臟移植之病患。較佳者為，使非晶型水飛薊賓適合於口服給藥。