CONG, FENG,HAO, HUAIXIANG,HSIEH, HSIN-I,JIANG, XIAOMO,LIU, JUN,NG, NICHOLAS
申请号：
CA2864306
公开号：
CA2864306A1
申请日:
2013.02.22
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
Disclosed are biomarkers, methods and assay for the identification of cancer patients who are predicted to benefit from the therapeutic administration of Wnt antagonist. The biomarkers include detection of RNF43 and ZNRF3 gene deletion, reduced RNF43 and ZNRF3 mRNA expression, reduced RNF43 and ZNRF3 protein expression, RNF43 and ZNRF3 inactivation mutation, phosphorylated LRP6, phophorylated Dishevelleds, and the expression of Frizzleds. These biomarkers can be associated with the better outcome for cancer patients treated with Wnt pathway inhibitors.
