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5-5 merged ring as C5A inhibitor
专利权人:
CHEMOCENTRYX; INC.
发明人:
PUNNA, SREENIVAS,MALI, VENKAT REDDY,MALATHONG, VIENGKHAM,LUI, REBECCA M.,LANGE, CHRISTOPHER W.,FAN, PINGCHEN,ZENG, YIBIN,ZHANG, PENGLIE
申请号:
ARP180101445
公开号:
AR111841A1
申请日:
2018.05.31
申请国别(地区):
AR
年份:
2019
代理人:
摘要:
1. Characteristic requirement 1: A compound whose characteristic is formula (1).The top of a.A 1 ring is selected from N, Ch, C (O) and C (R830808) groups.The vertices of a_ring are selected from N, Ch and C groups (R830808).Each Vertex of A-3 RingA8308;A. A8309A and A8310A were independently selected from group Ch and group C (R830808).Each dotted line link is independently marked as a double link or a simple link; R1 is selected from the group of - Okilun C833183288OG - direct link - Okilun C83216C833183288OG - Arilo C832683318321; R2 is selected from the group of - Okilun C833128OG - direct link;1. C83218331 No. 832831 leased land;Halogenated tar C83218C83331-8328;- c(o) - C832183318328A leased land;- c(o) - Arilo C8326C 8333183221; 8320;- C (o) - irregular, - C (o) - cyclo - C 83231- C (O) - heterosexual - C (O) Nr. 74191; R1 74955;- SO 832222-Arilo C8326283331;- So832222 - heterosexual, - C (o) - lessor C832131 - 8328A - O - heterosexual, - C (o) - lessor C8321832831 - O - Arilo C8326318321; - 8320;- C (o) - Rent C8321C83318328O - O - straight ring silicon - C (o) - Rent C83218331 - O - cycloquilo C832383331;- C (o) - Lessor C83218331832808 - Heterosexual, - C (o) - Lessor C83318328A - Arilo C8332833121; 8320;- C (o) - Lessor C8321C833183288A - Heterosexual - C (o) - Lessor C8331832883;Heterosexuality is a ring of four to eight members, consisting of one or three heteroatoms as the vertex of the ring selected from N, O and S. A. Aromatic rings consisting of 5 to 10 members in the heteromorphic group consisting of 1 to 3 heteromorphic atoms are selected as the annular vertices from N, O and S, in which R74919 and R7474955 should be selected from hydrogen group C83218383288383, respectively.A. Halogenated tar C8331832821;E.R1 can be replaced by R83091 to 5;RS749191 and RS74977 were selected from C83218331 and 832667 tenants respectively.Alcoxi C832188331636262;Halogenated tar C832183531832626,A. Halogenated tar-O-C8321E-8331832626;- S-lessor C83218832626;- C83218
来源网站:
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