Disclosed is an ambulatory therapeutic fluid delivery device (10). The device includes at least one housing (200) connectable to a cannula (250), the at least one housing retaining a reservoir (220) to hold the therapeutic fluid. The device also includes a mechanically powered pumping mechanism (150) to cause delivery of at least some of the fluid from the reservoir, and a power-transfer mechanism to transfer manually-delivered power provided by a user to mechanically actuate the pumping mechanism.