The present invention discloses a spray drying process characterized by continuous preparation and immediate spray drying of a solution comprising at least one active pharmaceutical ingredient and/or at least one excipient, and at least one solvent. The said active pharmaceutical ingredient(s) and solvent(s) are combined, alone or along with one or more excipients to form a first suspension. Said suspension is continuously fed to an intensifier pump that pushes said suspension through at least one micro-reaction chamber and/or at least one micro-channel where the suspension's solid(s) component(s) is(are) dissolved into said solvent(s) by means of high energy mixing / forced contact at micro, nano and molecular level to form a solution stream. The said solution stream is then immediately and continuously fed to the spray dryer through at least one atomization nozzle, drying said atomized stream to obtain solid particles and collecting said solid particles. Single component particles or multi-component particles, particulate amorphous solid dispersion and pharmaceutical compositions are also disclosed. The present invention also discloses amorphous solid dispersions obtained by the method of the invention as well as pharmaceutical compositions containing the same.La présente invention concerne un procédé de séchage par pulvérisation caractérisé par une préparation continue et un séchage par pulvérisation immédiat d'une solution comprenant au moins un ingrédient pharmaceutique actif et/ou au moins un excipient, et au moins un solvant. Ledit au moins un ingrédient pharmaceutique actif et ledit au moins un solvant sont combinés, seuls ou conjointement avec un ou plusieurs excipients pour former une première suspension. Ladite suspension est introduite en continu dans une pompe de renforcement qui pousse ladite suspension à travers au moins une chambre de micro-réaction et/ou au moins un micro-canal où le(s) composant(s) solide(s) de la suspension est(sont) dissous dans
