Ventilatory systems and methods are disclosed for detecting weaning readiness of a patient. In one aspect the method includes the steps of collecting patient data analyzing the collected patient data to generate at least one patient parameter comparing the at least one patient parameter to predetermined weaning readiness threshold criteria and providing an advisory proposition to a clinician indicating a readiness of the patient to start a weaning trial if the at least one patient parameter meets the weaning readiness threshold criteria. The weaning trial may additionally or alternatively be automatically executed if the at least one patient parameter meets the weaning readiness threshold criteria.
