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Production process of high purity prasugrel hydrochloride
专利权人:
Daiichi Sankyo Company, Limited;Ube Industries, Ltd.
发明人:
INOUE, Teruhiko,NAKAMURA, Kazuyoshi,HAGIHARA, Masahiko,MIYATA, Hiroyuki,WADA, Yukinori,YOKOTA, Naoyuki
申请号:
ES07741221
公开号:
ES2622514T3
申请日:
2007.04.06
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A process for the production of prasugrel hydrochloride represented by the formula: ** Formula ** with a reduced content of 5- (α-cyclopropylcarbonyl-2-fluorobenzyl) -2-oxo-2,4,5,6,7,7a -hexahydrothiene [3,2-c] pyridine comprising: preparing free prasugrel represented by the formula: ** Formula ** containing 5- (α-cyclopropylcarbonyl-2-fluorobenzyl) -2-oxo-2,4,5, 6,7,7a-hexahydrothiene [3,2-c] pyridine from a 2-silyloxy-5- (α-cyclopropylcarbonyl-2-fluorobenzyl) -4,5,6,7-tetrahydrothiene [3,2-c ] pyridine; dissolve the free prasugrel represented by formula (I) in an inert solvent; and optionally adding hydrochloric acid dropwise to the reaction solution.Un procedimiento de producción de clorhidrato de prasugrel representado por la fórmula:**Fórmula** con un contenido reducido de 5-(α-ciclopropilcarbonil-2-fluorobencil)-2-oxo-2,4,5,6,7,7a-hexahidrotieno[3,2-c]piridina que comprende: preparar prasugrel libre representado por la fórmula:**Fórmula** que contiene 5-(α-ciclopropilcarbonil-2-fluorobencil)-2-oxo-2,4,5,6,7,7a-hexahidrotieno[3,2-c]piridina a partir de una 2-sililoxi-5-(α-ciclopropilcarbonil-2-fluorobencil)-4,5,6,7-tetrahidrotieno [3,2-c]piridina; disolver el prasugrel libre representado por la fórmula (I) en un solvente inerte; y añadir el ácido clorhídrico opcionalmente gota a gota a la solución para la reacción.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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