CELLULES IMMUNITAIRES EFFECTRICES GÉNÉTIQUEMENT MODIFIÉES ET CELLULES MANIPULÉES POUR L'EXPANSION DE CELLULES IMMUNITAIRES EFFECTRICES

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专利权人:

Board of Regents; The University of Texas System

发明人:

申请号：

EP19152625.0

公开号：

EP3536707A1

申请日:

2015.11.05

申请国别(地区):

EP

年份:

2019

代理人:

摘要：

Chimeric antigen receptor (CAR) polypeptides (and immune effector cells expressing the CARs) are provided comprising modified hinge domain sequences. Also provided are engineered antigen presenting cells (APCs) that express transgenes encoding target antigen and human leukocyte antigen (HLA). In further aspect, immune effector cells are provided that have been selected for elevated mitochondrial spare respiratory capacity.

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中国工程科技知识中心

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http://www.ckcest.cn/home/