CELLULES IMMUNITAIRES EFFECTRICES GENETIQUEMENT MODIFIEES ET CELLULES MANIPULEES POUR L'EXPANSION DE CELLULES IMMUNITAIRES EFFECTRICES

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专利权人:

THE UNIVERSITY OF TEXAS SYSTEM;BOARD OF REGENTS

发明人:

COOPER, LAURENCE J.N.,SINGH, HARJEET,HULS, HELEN,OLIVARES, SIMON,JENA, BIPULENDU,PATEL, KRINA

申请号：

CA2964785

公开号：

CA2964785A1

申请日:

2015.11.05

申请国别(地区):

CA

年份:

2016

代理人:

摘要：

Chimeric antigen receptor (CAR) polypeptides (and immune effector cells expressing the CARs) are provided comprising modified hinge domain sequences. Also provided are engineered antigen presenting cells (APCs) that express transgenes encoding target antigen and human leukocyte antigen (HLA). In further aspect, immune effector cells are provided that have been selected for elevated mitochondrial spare respiratory capacity.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/