LIM, SUN KYUNG,임선경,LEE, HA YOUNG,이하영,KIM, YU MI,김유미,YOON, MYEONG SIK,윤명식,LIM, DONG KWON,임동권,CHO, IL HWAN,조일환,HONG, HYE SUK,홍혜숙,HONG, EUN MI,홍은미,PARK, SUN YOUNG,박선영,KIM, BONG TAE,김봉태,PARK, JIE EUN,박지은
申请号：
KR1020110087581
公开号：
KR1020130024254A
申请日:
2011.08.31
申请国别(地区):
KR
年份:
2013
代理人:
摘要：
PURPOSE: A nanoparticle using a pegylated chitosan-bile acid complex and a method for preparing the same are provided to continuously release a drug in the body with a low toxicity.CONSTITUTION: A pegylated chitosan-bile acid complex is an amphiphilic complex containing polyethylene glycol and hydrophobic bile acid which are conjugated to chitosan. The pegylated chitosan-bile acid complex forms a self-aggregate in water. Polyethylene glycol is selected from a group consisting of PEG and a derivative thereof.COPYRIGHT KIPO 2013본 발명은 1 내지 10 KDa의 키토산에 폴리에틸렌 글리콜과 소수성 담즙산이 결합되어 수중에서 자기 집합체(self-aggregation)를 형성하는 페길화된 키토산-담즙산 복합체, 상기 복합체 내부에 소수성 약물이 봉입된 나노입자, 그 나노입자를 포함하는 주사제 및 그 나노입자의 제조방법을 제공한다.
