James O. McNamara,Xiao-Ping He,Yangzhong Huang,Bin Gu,Enhui Pan
申请号：
US13030977
公开号：
US08507438B2
申请日:
2011.02.18
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The invention provides pharmaceutical compositions and methods of use thereof for preventing or ameliorating disorders of the nervous system. More specifically, the invention provides pharmaceutical compositions, including phosphopeptides, that when administered disrupt TrkB-mediated activation of PLCγ1 phosphorylation. The invention further provides method of treatment comprising administering inhibitors of TrkB-mediated activation of PLCγ1 phosphorylation alone or in combination with other pharmaceutical compositions to prevent or ameliorate nervous system disorders such as epilepsy, stroke, anxiety, migraine, and pain.
