James O. McNamara,Xiao-Ping He,Yangzhong Huang,Bin Gu
申请号：
US16436867
公开号：
US20190374602A1
申请日:
2019.06.10
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The invention provides pharmaceutical compositions and methods of use thereof for preventing or ameliorating disorders of the nervous system. More specifically, the invention provides pharmaceutical compositions, including phosphopeptides that when administered disrupt the physical interaction of TrkB with its signaling effector, phospholipase Cγ1 (PLCγ1). The invention further provides method of treatment comprising administering phosphopeptides that uncouple TrkB from PLCγ1 in order to prevent and/or ameliorate nervous system disorders such as epilepsy, anxiety, and seizures.
