The present invention provides a compound of formula I；or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, A1, X, X1, s and n are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides pharmaceutical composition of the compounds of the invention and a combination of pharmacologically active agents and a compound of the invention.本發明提供式I化合物；或其醫藥學上可接受之鹽，其中R1、R2、R3、A1、X、X1、s及n如本文所定義。本發明亦關於製造本發明化合物之方法，及其治療用途。本發明另外提供本發明化合物之醫藥組合物及藥理學活性劑與本發明化合物之組合。
