ANTAGONISTES DES RÉCEPTEURS DE L'ANGIOTENSINE II

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专利权人:

MERCK SHARP & DOHME CORP.;NICOX S.A.

发明人:

申请号：

EP07862716.3

公开号：

EP2121665B1

申请日:

2007.12.11

申请国别(地区):

EP

年份:

2014

代理人:

摘要：

A compound having the structure wherein R is an angiotensin receptor antagonist active group, Y is -Y1-Y2-Y3-Y4-Y5-； Y1 is C(R1R2)； R1 is selected from the group consisting of hydrogen and C1-4 alkyl； R2 is selected from the group consisting of hydrogen, C1-4 alkyl, and &mdash；OC(O)C1-4 alkyl； Y2 is O or CH2； Y3 is C(O) or CH2； Y4 is O or CH2； Y5 is &mdash；(CH2)1-2&mdash；(X)0-1&mdash；(CH2)0-1&mdash； or is absent； X is &mdash；O&mdash； or &mdash；CR3R4&mdash；； and R3 and R4 are independently selected from the group consisting of hydrogen and C1-C4 alkyl； or a pharmaceutically acceptable salt or hydrate thereof, which is useful for treating hypertension.

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