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METHODS AND POLYMER COMPOSITIONS FOR TREATING RETINAL DETACHMENT AND OTHER OCULAR DISORDERS
专利权人:
MASSACHUSETTS EYE AND EAR INFIRMARY
发明人:
STEFATER, JAMES ANTHONY, III,STRYJEWSKI, TOMASZ PAWEL
申请号:
CA3030767
公开号:
CA3030767A1
申请日:
2017.07.13
申请国别(地区):
CA
年份:
2018
代理人:
摘要:
The invention provides methods and polymer compositions for treating retinal detachment and other ocular disorders, where the methods employ polymer compositions that can form a hydrogel in the eye of a subject. The hydrogel is formed by reaction of (i) a nucleo-functional polymer that is a biocompatible polymer containing a plurality of thio-functional groups -R1-SH wherein R1 is an ester-containing linker, such as a thiolated poly(vinyl alcohol) polymer and (ii) an electro-functional polymer that is a biocompatible polymer containing at least one thiol-reactive group, such as a poly(ethylene glycol) polymer containing alpha-beta unsaturated ester groups.
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中国工程科技知识中心
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