KO, HYO JIN,고효진,KIM, YONG CHUL,김용철,LEE, SUN MI,이선미,LEE, WON GIL,이원길
申请号：
KR1020120012139
公开号：
KR1020130090976A
申请日:
2012.02.07
申请国别(地区):
KR
年份:
2013
代理人:
摘要：
PURPOSE: Alpha, beta-unsaturated lactone derivatives are provided to suppress the production of interleukin-2 (IL-2), thereby preventing or treating various diseases caused by an abnormal immune response.CONSTITUTION: Alpha, beta-unsaturated lactone derivatives, which are represented by chemical formula 1, pharmaceutically accepted salts, solvates, and hydrates thereof are provided. The &alpha,&beta-unsaturated lactone derivatives suppress the production of interleukin-2 (IL-2). A pharmaceutical composition for the prevention or treatment of transplant rejection, autoimmune diseases, inflammation diseases, and allergic diseases comprises the pharmaceutically effective doses of the &alpha,&beta-unsaturated lactone derivatives and pharmaceutically acceptable salts.COPYRIGHT KIPO 2013본 발명은 α,β-불포화 락톤 유도체, 그의 약제학적으로 허용되는 염, 용매화물 또는 수화물에 관한 것으로서, 본 발명의 α,β-불포화 락톤 유도체는 인터루킨-2(IL-2) 생산을 억제하여, 비이상적인 면역반응에 의해 야기되는 다양한 질환을 예방 또는 치료할 수 있다. 따라서 본 발명의 α,β-불포화 락톤 유도체는 인터루킨-2-관련 연구뿐 아니라, 면역억제제로서도 유용하다.
