BAXALTA INCORPORATED;BAXALTA GMBH;BROOKHAVEN SCIENCE ASSOCIATES, LLC;RESEARCH FOUNDATION OF THE STATE UNIVERSITY OF NEW YORK
发明人:
Brian A. Crowe,Ian Livey,Maria O'Rourke,Michael Schwendinger,John J. Dunn,Benjamin J. Luft,Maria ORourke
申请号：
US15049438
公开号：
US09895434B2
申请日:
2016.02.22
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The invention relates to the development of chimeric OspA molecules for use in a new Lyme vaccine. More specifically, the chimeric OspA molecules comprise the proximal portion from one OspA serotype, together with the distal portion from another OspA serotype, while retaining antigenic properties of both of the parent polypeptides. The chimeric OspA molecules are delivered alone or in combination to provide protection against a variety of Borrelia genospecies. The invention also provides methods for administering the chimeric OspA molecules to a subject in the prevention and treatment of Lyme disease or borreliosis.
