Michael Schwendinger;Ian Livey;Benjamin J. Luft;John J. Dunn;Maria O'Rourke;Brian A. Crowe
发明人:
Brian A. Crowe,Ian Livey,Maria O'Rourke,Michael Schwendinger,John J. Dunn,Benjamin J. Luft,Maria ORourke
申请号：
US13107796
公开号：
US08623376B2
申请日:
2011.05.13
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The invention relates to the development of chimeric OpsA molecules for use in a new Lyme vaccine. More specifically, the chimeric OspA molecules comprise the proximal portion from one OspA serotype, together with distal portion from another OspA serotype, while retaining antigenic properties of both of the parent polypeptides. The chimeric OspA molecules are delivered alone or in combination to provide protection against a variety of Borrelia genospecies. The invention also provides methods for administering the chimeric OspA molecules to a subject in the prevention and treatment of Lyme disease or borreliosis.
