Pharmaceutical compositions for treating infection from Helicobacter pylori. are described, containing, as the active ingredients, polysorbate and an antibiotic selected from clarithromycin, metronidazole and a mixture thereof.The invention also concerns the use of such compositions as anti-infective agents for the H. pylori eradication treatment, in particular in a combined therapy with a second antibiotic agent and with a gastric proton pump inhibiting agent, or an antacid, or an H2 receptor antagonist, in a therapeutic protocol known as “triple therapy” for the treatment of peptic ulcer.