The present invention provides a mutant chicken interleukin-1β protein as chicken interleukin-1β antagonist, which has a substituted peptide at position 117 and/or 118 of wild-type chicken interleukin-1β peptides. The mutant chicken interleukin-1β protein is created by using point mutation in a method genetic engineering it can significantly inhibit proliferation of avian virus, such as avian influenza virus, avian reovirus and Mareks disease, and inflammation reaction. Therefore, the mutant chicken interleukin-1β protein of the present invention can be used as antiviral and anti-inflammatory medication.本發明提供一種作為雞介白素-1β拮抗物的變異型雞介白素-1β蛋白質,其係具有野生型雞介白素-1β胺基酸序列的第117個及/或第118個胺基酸位置被另一個胺基酸取代的變異。該變異型雞介白素-1β蛋白質係利用基因單點突變法以基因工程技術改造設計而成,其能有效抑制例如禽流感、里奧病毒以及馬立克病之家禽病毒增殖以及家禽發炎反應。因此,本發明之變異型雞介白素-1β蛋白質可應用於家禽疾病的抗病毒、抗發炎等醫療用途。
