A compound of Formula Ia: ** Formula ** in which: Q is a radical selected from phenyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 1,2,4-oxadiazolyl and thiazolyl； wherein said phenyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl and thiazolyl of Q is optionally substituted with up to 3 radicals independently selected from halo, C1-6 alkyl, C1-6 alkoxy, C1-6 alkyl, -C (O) OR20 and - C (O) R20 halo-substituted； where R20 is selected from hydrogen and C1-6 alkyl； wherein a carbon adjacent to W2 is connected through a CR31 or O with a carbon of Q to form a 5-membered ring fused with rings A and Q； where R31 is selected from hydrogen and C1-6 alkyl； W1 and W2 are independently selected from CR21 and N； where R21 is selected from hydrogen, cyano, C1-6 alkyl, -C (O) OR25, where R25 is selected from hydrogen and C1-6 alkyl； Ring A may have up to 2 carbons in the ring substituted with a group selected from -C (O) -, - C (S) - and -C (>； = NOR30) - and may be partially unsaturated with up to 2 double bonds； where R30 is selected from hydrogen and C1-6 alkyl； L is selected from C1-6 alkylene, C2-6 alkenylene, - (CH2) nO-, -NR26 (CH2) n-, -OC (O) (CH2) n-, -C (O) O (CH2) n - and -O (CH2) n-； where R26 is selected from hydrogen and C1-6 alkyl； where n is selected from 1, 2, 3, 4 and 5； wherein any alkyl of L may be optionally substituted with 1 to 3 radicals independently selected from halo, C1-6 alkyl, halo- substituted C1-6 alkyl, C1-6 alkoxy, halosubstituted C1-6 alkoxy, -C (O) R22 and -C (O) OR22； where R22 is selected from hydrogen and C1-6 alkyl； t1 and t2 are each independently selected from 0, 1 and 2； q is selected between 0, 1, 2, 3 and 4； R1 is selected from -X1S (O) 0-2X2R6a, -X1S (O) 0-2X2OR6a, -X1S (O) 0-2X2C (O) OR6a, - X1S (O) 0-2X2OC (O) R6a and -X1S (O) 0-2NR6aR6b； where X1 is selected from a bond, O, NR7a and C1-4 alkylene, where R7a is independently selected from hydrogen and C1-6 alkyl； X2 is selected from a bond and C1-4 alkylene； R6a is selected f
