JANG, MYUNG HYUN,KIM, MIN YOUNG,LEE, JONG-SOO,KIM, DAE JIN,BAE, SUNG MIN,KWON, SE CHANG
申请号：
MYPI 2014002586
公开号：
MY165211A
申请日:
2013.03.08
申请国别(地区):
MY
年份:
2018
代理人:
摘要：
DISCLOSED IS A METHOD FOR THE PREPARATION OF A COMPLEX IN WHICH A PHYSIOLOGICALLY ACTIVE POLYPEPTIDE IS COVALENTLY BONDED TO AN IMMUNOGLOBULIN CONSTANT REGION VIA A NON-PEPTIDYL LINKER. THE METHOD IS CHARACTERIZED BY THE EMPLOYMENT OF A REDUCING AGENT, BY WHICH CONVENTIONAL PROBLEMS OF LOW PRODUCTION YIELD AND MODIFICATION OF THE POLYPEPTIDE CAN BE OVERCOME. THE PHYSIOLOGICALLY ACTIVE POLYPEPTIDE-NON-PEPTIDYL POLYMER-IMMUNOGLOBULIN CONSTANT REGION COMPLEX CAN BE PRODUCED WITH HIGH PURITY AND YIELD AS WELL AS AT LOW COST. THUS, THE METHOD IS INDUSTRIALLY USEFUL. MOREOVER, BY EXHIBITING A PROLONGED ACTION PROFILE, THE PHYSIOLOGICALLY ACTIVE POLYPEPTIDE-NON-PEPTIDYL POLYMER-IMMUNOGLOBULIN CONSTANT REGION COMPLEX CAN BE EFFECTIVELY USED FOR DEVELOPING LONG-ACTING FORMULATIONS OF PHYSIOLOGICALLY ACTIVE POLYPEPTIDES WHICH HAVE IMPROVED DRUG COMPLIANCE.
