XETRIOS THERAPEUTICS, INC.;SALK INSTITUTE FOR BIOLOGICAL STUDIES
发明人:
LEMKE, GREG E.,FRITZ, LAWRENCE C.,VOLLRATH, BENEDIKT,ROTHLIN, CARLA V.
申请号：
CA2879542
公开号：
CA2879542A1
申请日:
2013.07.23
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
The present disclosure provides methods for modulating the interaction between a TAM ligand and a lipid membrane containing phosphatidyl serine (PtdSer). In one example, such methods use a TAM receptor agonist having a PtdSer -containing lipid bilayer membrane with Gas6 and/or Protein S bound to the membrane to activate signaling from one or more TAM receptors and treat an autoimmune disease. In another example, methods are provided for treating a subject with a pathological condition characterized by overactivation of TAM signaling and/or reduction in Type I IFN response, such as infection by an enveloped virus, by use of agents that decrease the interaction between a TAM ligand and PtdSer. Also provided are methods for classifying a virus as susceptible to anti-TAM therapy. Methods of identifying an agent that blocks virus infectivity are also provided.
