PERREAU, VICTORIA MARY,FIELD, JUDITH,BINDER, MICHELE D,KILPATRICK, TREVOR
申请号：
CA2808668
公开号：
CA2808668A1
申请日:
2011.08.19
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
Methods, compositions and kits based on TAM receptors, or TAM receptor ligands or agonists are provided for detection of neuropathological diseases or determination of their progression. The neural diseases in particular include multiple schlerosis or other inflammatory neural disorders that are characterized by demyelination, oligodendrocyte cytotoxicity and microglial activation. These methods include screening cells of a subject where identification of an elevation of expression of a TAM receptor or a change in expression of a TAM receptor ligand is diagnostic of the disease presence or progression. In addition treatment of subjects with such neuropathological diseases by administering TAM receptor ligands (such as GAS 6 or Protein S) or by administering agonists such as antibodies specific for the TAM receptors； Axl, Mer or Tyro3 is described.
