William J. Greenlee;Yuanzan C. Ye;Jared N. ;Brian McKittrick;John Caldwell;Johannes H. Voigt;Zhaoning Zhu;Robert D. Mazzola, Jr.;Corey O. Strickland;Elizabeth M. Smith;Andrew W. Stamford;Zhong-Yue Sun
发明人:
Zhaoning Zhu,Brian McKittrick,Zhong-Yue Sun,Yuanzan C. Ye,Johannes H. Voigt,Corey O. Strickland,Elizabeth M. Smith,Andrew W. Stamford,William J. Greenlee,Robert D. Mazzola, Jr.,John Caldwell,Jared N.
申请号：
US12480391
公开号：
US08178513B2
申请日:
2009.06.08
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Disclosed are compounds of the formula Ior a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein W, U, X, R1, R2, R3, and R4 are as defined herein, and pharmaceutical compositions comprising the compounds of formula I. Also disclosed are methods of using such compounds to inhibit aspartyl protease and to treat a variety of disease or disorders, including cardiovascular diseases, cognitive and neurodegenerative diseases. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic antagonist
