Anna E. Maciag,Larry K. Keefer,Joseph E. Saavedra,Xinhua Ji,Vandana Kumari
申请号：
US14352096
公开号：
US20140315865A1
申请日:
2012.10.18
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Disclosed are hybrid compounds that release both nitric oxide and a moiety that inhibits poly (ADP-ribose) polymerase (PARP), e.g., a compound or a pharmaceutically acceptable salt thereof of formula (I), wherein R1-4 and m-p are as described herein. Also disclosed are pharmaceutical compositions and methods of use including treating cancer and enhancing the chemotherapeutic treatment of chemotherapeutic agents and high energy radiation.
