YU, Jiang,WU, Guosheng,YUEN, Po-Wai,VILLEMURE, Elisia,SCHWARZ, Jacob,LY, Cuong,SELLERS, Benjamin,VOLGRAF, Matthew
申请号：
ES14781878
公开号：
ES2690355T3
申请日:
2014.10.08
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound of formula (II): ** Formula ** wherein Ra is C1-6 alkyl or C2-6 alkenyl, each optionally substituted with one or more Rb substituents； C2-6 alkynyl； halo； -C (O) Rc； -NRdRe； -C (O) NRdRe； -C (S) NRdRe； -C (>； = N-OH) -C 1-4 alkyl； -C 1-4 alkyl； -Chaloalkyl C1-4； -C1-4 alkyl； -SO2 C1-4alkyl； cyano； C3-6 cycloalkyl optionally substituted with one or more Rf substituents； or a phenyl, monocyclic heteroaryl or heterocycloalkyl ring, each ring optionally substituted with one or more Rg substituents； wherein each Rb substituent is independently selected from the group consisting of -OH, -C 1-4 alkoxy, -NRdRe, -C (O) NRdRe, -C1-4 alkyl, -SO2C 1-4 alkyl, cyano, halo, cycloalkyl C3-6 and monocyclic heteroaryl； Rc is C1-4 alkyl, C1-4 haloalkyl, C3-6 cycloalkyl or a carbon monocyclic heterocycloalkyl； Rd is H or C1-4 alkyl； Re is H； C1-4 alkyl optionally substituted with -CN, -CF3, -OH or a monocyclic heterocycloalkyl； C3-6 cycloalkyl； -OH； or C1-4alkoxy； or Rd and Re, taken together with the nitrogen to which they are linked, form a heterocycloalkyl, optionally substituted with C1-4 alkyl or -OH； each Rf substituent is independently selected from the group consisting of: C1-4 alkyl optionally substituted with -OH, cyano or C1-4 alkoxy； -OH； halo； C1-4 haloalkyl； -CONH2； and cyano； and each Rg substituent is independently selected from the group consisting of C1-4 alkyl, -CF3, halo, -NH2, -OCH3, cyano and -OH； R 1 is selected from the group consisting of H, C 1-6 alkyl, C 1-4 haloalkyl, C 3-6 cycloalkyl, halo, -C 1-4 alkyl, -C 1-4 haloalkyl, cyano and -C (O) C 1-4 alkyl ； or Ra and R1, taken together with the carbons to which they are attached, form a 5 to 7 member ring, optionally containing an O or NH, and optionally substituted with one or more Rh substituents； wherein each Rh substituent is independently -C (O) NRiRj, cyano, or is C1-4 alkyl optionally substituted with -OH, -OCH3, cyano, or -C (O) NRiRj； or two Rh groups, bonded to the same carbon and taken to
