ANDERSON, ANNALIESA SYBIL,安德森 安娜丽沙,安德森 安娜麗沙,DONALD, ROBERT G. K.,当那德 罗伯特,當那德 羅伯特,FLINT, MICHAEL JAMES,佛林特 麦可,佛林特 麥可,JANSEN, KATHRIN UTE,杰森 凯萨琳,傑森 凱薩琳,KALYAN, NARENDER K.,卡雅恩 那伦德,卡雅恩 那倫德,MININNI, TERRI
申请号：
TW108114747
公开号：
TW201932481A
申请日:
2012.04.20
申请国别(地区):
TW
年份:
2019
代理人:
摘要：
In one aspect, the invention relates to an immunogenic composition that includes a mutant Clostridium difficile toxin A and/or a mutant Clostridium difficile toxin B. Each mutant toxin includes a glucosyltransferase domain having at least one mutation and a cysteine protease domain having at least one mutation, relative to the corresponding wild-type C. difficile toxin. The mutant toxins may further include at least one amino acid that is chemically crosslinked. In another aspect, the invention relates to antibodies or binding fragments thereof that binds to said immunogenic compositions. In further aspects, the invention relates to isolated nucleotide sequences that encode any of the foregoing, and methods of use of any of the foregoing compositions.在一態樣中，本發明關於包含難養芽胞梭菌之突變毒素A及/或難養芽胞梭菌之突變毒素B之免疫原性組成物。各突變毒素相較於對應之難養芽胞梭菌野生型毒素包含具有至少一個突變之糖基轉移酶結構域及具有至少一個突變之半胱胺酸蛋白酶結構域。該等突變毒素可另包含至少一個經化學交聯之胺基酸。在另一態樣中，本發明關於與該免疫原性組成物結合之抗體或彼之結合片段。在其他態樣中，本發明關於編碼前述任一者之經分離之核苷酸序列，及使用前述組成物之任一者之方法。
