SIDHU MANINDER K,DONALD ROBERT G K,KALYAN NARENDER K,MORAN JUSTIN KEITH,FLINT MICHAEL JMAES,ANDERSON ANNALIESA SYBIL,JANSEN KATHRIN UTE,MININNI TERRI L,RUPPEN MARK E
申请号：
ZA201307818
公开号：
ZA201307818B
申请日:
2013.10.21
申请国别(地区):
ZA
年份:
2014
代理人:
摘要：
In one aspect, the invention relates to an immunogenic composition that includes a mutanttoxin A and/or a mutanttoxin B. Each mutant toxin includes a glucosyltransferase domain having at least one mutation and a cysteine protease domain having at least one mutation, relative to the corresponding wild-typetoxin. The mutant toxins may further include at least one amino acid that is chemically crosslinked. In another aspect, the invention relates to antibodies or binding fragments thereof that binds to said immunogenic compositions. In further aspects, the invention relates to isolated nucleotide sequences that encode any of the foregoing, and methods of use of any of the foregoing compositions.
