The present invention relates to novel compounds that inhibit Lp-PLA2 activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases associated with the activity of Lp-PLA2, for example atherosclerosis, Alzheimer’s disease.本發明係關於能抑制Lp-PLA2活性的新穎化合物、其製備方法、包含該化合物的組成物以及其在治療與Lp-PLA2活性關連之疾病,例如動脈粥狀硬化、阿茲海默症的用途。