The present invention relates to novel compounds that inhibit Lp-PLA2 activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases associated with the activity of Lp-PLA2, for example atherosclerosis, Alzheimer’s disease.本發明係有關抑制Lp-PLA2活性之新穎化合物、其製備方法、含其之組成物及其治療Lp-PLA2活性關聯疾病(例如動脈粥樣硬化症、阿茲海默症)之用途。