In addition, the methods of preparing substitute ethylene oxide and its derivatives are also introduced. Pepper derivatives have been selected as the raw materials to replace the present cinmimi derivatives with Wittig reaction and acid amine condensation reaction. In addition, the use of these compounds in the prevention and treatment of depressive mental illness has also been introduced. 1. Characteristic 1: it is composed of a general formula (1) and its acceptable additive salt, wherein R1 is h, oh, F, Cl, Br, I, oc832323；OCF83223,OCHF₂,OCH₂F, CF₃,CHF83222,CH F CHCH₃CH₂,CF₃CH₂,CN, NO₂,Nh832222 or coor3；said R³ is H, a linear hydrocarbon chain C₁₋₁₀,a C₃₋₁₀ branched hydrocarbon chain,a C₃₋₁₀ cyclic hydrocarbon radical or a C₆₋₁₀ aromatic hydrocarbon radical；N represents 0, 1, 2 or 3, and the unit represented by the formula (2) contains at least one simple or double carbon link； X represents = O, = s, h, SH or SR3；This is n or nram,O or S, where R³ is H, a linear hydrocarbon chain C₁₋₁₀,a C₃₋₁₀ branched hydrocarbon chain,a C₃₋₁₀ cyclic hydrocarbon radical or a C₆₋₁₀ aromatic hydrocarbon radical；R2 is h, a linear Carbide chain c832183；a C₃₋₁₀ branched hydrocarbon chain,a. C83323-833318321； - 8320；an aromatic hydrocarbon radical C₆₋₁₀,a C₁₋₁₀-alkyl alcohol group or a group of N-substituted piperazine derivatives； or R² is a group that forms a tetrahydropyrrolyl, piperidyl, or hexamethyleneimino group with the neighboring Y.Se describe también el método para preparar las cinamamidas sustituidas y sus derivados de la presente. Se seleccionan derivados de piperonal como materiales de partida para preparar los derivados de cinamamida sustituida de la presente mediante una reacción de Wittig y una reacción de condensación ácido-amina, Además, se describe un uso de los presentes compuestos para prevenir y tratar enfermedades mentales de tipo depresivo. Reivindicación 1: Un compuesto de una fórmula general (1) y sus sales de adición de ácido farmacéuticamente aceptables, e
