This is a pluggable plasma discharge tube device having a replaceable discharge tube and a hand-held shell into which the replaceable discharge tube is plugged. There is a single electrode inside of the tube and no other electrodes outside. This electrode is connected to an output of a power supply and another output of the power supply is connected to a ground wire of its circuit. The input of the power supply is a 12V or lower, DC (direct current) source, or a battery. The plasma is generated via a contact-tube outside discharge, or a plasma jet from the tube, that uses working inert gas. The plasma discharge tube will produce atmospheric pressure, cold quasi-glow plasma, which can be used for sensitive surface disinfection, sterilization, as well as facial skin rejuvenation, treatment of skin tissue infections and destruction of cancer cells.