VACCARO, WAYNE,TORTOLANI, DAVID R.,DODD, DHARMPAL S.,HUYNH, TRAM N.,MUSSARI, CHRISTOPHER P.,CHEN, ZHONG,WROBLESKI, STEPHEN T.,LIU, CHUNJIAN,LIN, JAMES,TOKARSKI, JOHN S.
申请号：
TW95135141
公开号：
TWI441825B
申请日:
2006.09.22
申请国别(地区):
TW
年份:
2014
代理人:
摘要：
Compounds having the formula (1), and enantiomers, and diastereomers, pharmaceutically-acceptable salts, thereof, are usefuil as kinase modulators, including MK2 modulation, wherein one of E and F is a nitrogen atom and the other of E and F is a carbon atom, Z is N or CR<；SUB>；3<；/SUB>；, and R<；SUB>；1<；/SUB>；, R<；SUB>；2<；/SUB>；, R<；SUB>；3<；/SUB>；, X and Y are as defined herein.
