The present invention aims to provide a manufacturing method of plant fermentation extract containing safe, cheap, and highly concentrated immunization reactivating substances. The fermentation and cultivation method of this invention uses the rice pathogenic bacteria (Pantoea agglomerans) of gram-negative bacteria symbiotically living in plants of wheat or apple and the like to facilitate fermentation of plant components of wheat meal, and significantly enhance the immunization reactivating effect possessed by plants. The plant fermentation extract is free of the problem of mixing with impurities from animal ingredients, and is highly safe accordingly.本發明係關於提供一種製造含有安全便宜且高濃度之免疫賦活物質的植物發酵萃取物之方法作為課題,本發明的發酵及培養方法為,使用共生於小麥或蘋果等植物的革氏陰性菌之稻穀病原細菌(Pantoea agglomerans)使小麥粉等植物成分發酵,並顯著增強植物所具有的免疫賦活作用。且這些不會有混入來自動物成分之雜質的問題,故安全性高。
