COMPOSITION MÉDICINALE UTILISABLE POUR PRÉVENIR ET/OU TRAITER UNE ANOMALIE DU FACTEUR IX DE LA COAGULATION SANGUINE, COMPRENANT UNE MOLÉCULE DE LIAISON D'ANTIGÈNE MULTISPÉCIFIQUE REMPLAÇANT LA FONCTION DU FACTEUR VIII DE LA COAGULATION SANGUINE
Public University Corporation Nara Medical University;Chugai Seiyaku Kabushiki Kaisha
发明人:
申请号：
EP18776553.2
公开号：
EP3603670A1
申请日:
2018.03.30
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
The present inventors examined the procoagulant activity of a multispecific antigen-binding molecule that functionally substitutes for FVIII using blood and plasma derived from FIX disorder patients. The result showed that multispecific antigen-binding molecules that functionally substitute for FVIII can be used not only as methods for preventing and/or treating bleeding in hemophilia A, acquired hemophilia A, von Willebrand disease, and hemophilia C, which are caused by FVIII dysfunction, but also as methods for preventing and/or treating bleeding in FIX disorders, because of their procoagulant activity. Furthermore, the effect of a FIX formulation could be enhanced by using it in combination with a multispecific antigen-binding molecule that functionally substitutes for FVIII, and it was shown that the combined use is promising as a combination therapy that shows stable hemostatic effects.
