PROBLEM TO BE SOLVED: To provide pharmaceutical compositions for inhibiting recurrence, aggravation, and metastasis of hepatocarcinoma.SOLUTION: Heparanase is a kind of endogenous glucuronidase and has an important effect on tumor metastasis and angiogenesis. The pharmaceutical composition contains a sulfurated oligosaccharide compound having a phosphate group that inhibits heparanase activity, a pharmaceutically acceptable diluent, excipient, or carrier. The raw material of the active ingredient of the pharmaceutical composition is obtained from the yeast Pichia holstii. The active ingredient is mainly prepared by steps, such as a culture and fermentation of the yeast, as well as a hydrolysis, purification, and sulfuration of products. The therapeutically effective amount of the pharmaceutical composition is 80 to 315 mg/day, and is 160 mg/day preferably.SELECTED DRAWING: NoneCOPYRIGHT: (C)2017,JPO&INPIT【課題】肝癌の再発、悪化および転移の抑制に用いる医薬組成物の提供。【解決手段】ヘパラナーゼは内因性グルクロニダーゼの一種であり、腫瘍転移及び血管新生に重要な影響を与える。ヘパラナーゼの活性を阻害する燐酸基を有する硫酸化オリゴ糖化合物、医薬的に許容可能な希釈剤、賦形剤又はキャリアを含む医薬組成物。前記医薬組成物の有効成分の原料は、酵母菌Pichia holstiiから得られ、有効成分は、主に、酵母菌の培養と発酵、生成物の加水分解、精製及びスルホン化などのステップによって調製される医薬組成物。治療有効量は、80~315mg/日であり、好ましくは160mg/日である医薬組成物。【選択図】なし
