The invention discloses a new use of ±-Mangostin in medicine, which is application of ±-Mangostin in preparation of medicaments for Alzheimers disease. Under the new working concentration, ±-Mangostin showed the capability to inhibit the aggregation and deposition of A². Moreover, it displayed the neuroprotective effect against neurotoxicity caused by A² oligomer, which maintained normal morphology of mammalian neuron cells, enhanced their normal physiological function, and realized the intervention in pathological process of Alzheimers disease. The invention provided a new approach to treat Alzheimers disease.
