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促進細胞攝入粒子之混合物及其製備方法
专利权人:
发明人:
马蕴华,馬蘊華,吕彦礼,呂彥禮,吴建德,吳建德,魏国珍,魏國珍,吕怡青,呂怡青
申请号:
TW101118169
公开号:
TWI583395B
申请日:
2012.05.22
申请国别(地区):
TW
年份:
2017
代理人:
摘要:
A composition for enhancing cellular uptake of carrier particles comprises a delivery system for a drug or biochemical molecule and a polyphenolic compound, wherein the polyphenolic compound is added to the drug or biochemical molecule delivery system to enhance cellular uptake of drug or biochemical molecules carried by the delivery system. A method for the same is also disclosed, wherein a polyphenolic compound or its derivative is mixed with an existing delivery system for drug or biochemical molecule, and the mixture is used to deliver drug or biochemical molecules into cells or an organism. The method is easy to operate and does not require further chemical reaction in process of the existing delivery system. The delivery system may include a magnetic carrier that can be guided to a specified region by an external magnetic field, consequently increased the amount of the drug or biochemical molecules acting on target cells.本發明係一種促進細胞攝入粒子之混合物,其係利用添加多酚類化合物及其衍生物於一藥物或生物性分子輸送系統中,以提升藥物或生物性分子輸送系統所攜帶之一藥物或生物性分子被攝入細胞之總量。在針對多酚類化合物及其衍生物之此一特性進行利用時,僅需將多酚類化合物及其衍生物與一現行之藥物或生物性分子輸送系統進行混合,並遞送至一生物體內,此應用具有操作簡單且不影響現行輸送系統之優點。更甚者,此藥物或生物性分子輸送系統可包含一磁性載體,可藉由一外加磁場進一步將載體引導至一特定作用部位,以提升藥物或生物性分子作用於特定細胞之總量。
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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